Hsf2bp brca2
Web26 aug. 2024 · HSF2BP encodes an interactor of the heat-shock response transcription factor HSF2 ( Yoshima et al., 1998 ). During the course of this work and, in agreement … Web26 aug. 2024 · Hsf2bp S167L/S167L females show reduced fertility with smaller litter sizes. To obtain mechanistic insights, we identified C19ORF57/BRME1 as a strong interactor …
Hsf2bp brca2
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WebHSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis Graphical Abstract Highlights dHSF2BP forms a direct evolutionarily conserved interaction with BRCA2 dLossofHSF2BPdisruptsmeiotichomologousrecombination in spermatogenesis dIn … WebARTICLE BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination Rania Ghouil1,10, Simona Miron1,10, Lieke Koornneef 2,10, Jasper Veerman 3, Maarten W. Paul 3, Marie-Hélène Le Du1, Esther Sleddens-Linkels4, Sari E. van Rossum-Fikkert3,5, Yvette van Loon3, Natalia Felipe-Medina6, Alberto M. …
Web29 jul. 2024 · BRCA2 and its interactors are required for meiotic homologous recombination (HR) and fertility. Loss of HSF2BP, a BRCA2 interactor, disrupts HR during … Web31 mrt. 2024 · HSF2BP is a BRCA2 ( 600185 )-interacting protein required for homologous recombination during spermatogenesis ( Brandsma et al., 2024 ). In somatic cells, …
Web21 mrt. 2024 · HSF2BP (Heat Shock Transcription Factor 2 Binding Protein) is a Protein Coding gene. Diseases associated with HSF2BP include Premature Ovarian Failure 19 . … Web13 feb. 2024 · Here we identify a meiotic localizer of BRCA2, MEILB2/HSF2BP, that localizes to the site of meiotic DSBs in mice. Disruption of Meilb2 abolishes the …
Web21 mrt. 2024 · HSF2 binding protein (HSF2BP) associates with HSF2. The interaction occurs between the trimerization domain of HSF2 and the amino terminal hydrophilic region of HSF2BP that comprises two leucine zipper motifs. HSF2BP may therefore be involved in modulating HSF2 activation. [provided by RefSeq, Jul 2008] Associated conditions
Web5 mrt. 2024 · BRCA2/HSF2BP complex associated protein) as a key component of the meiotic recombination machinery. Our studies show that a single substitution (S167L) in HSF2BP leads to a reduction in the loading of both MIDAP and HSF2BP at the recombination nodules. Furthermore, our results suggest that meiotic progression … gartner crm reportgartner crm 2021Web21 mrt. 2024 · BRCA2 (BRCA2 DNA Repair Associated) is a Protein Coding gene. Diseases associated with BRCA2 include Fanconi Anemia, Complementation Group D1 … gartner critical capabilities itsmWeb29 jul. 2024 · HSF2BP ARM binds disordered BRCA2 peptide with high affinity. Our previous analyses using coimmunoprecipitation identified the C-terminal part of HSF2BP I93-V334 and the BRCA2 fragment G2270-T2337 (F9) as interacting regions 16.Extending this approach (Fig. 1a–c, Supplementary Fig. 1a, b), we narrowed down the minimal … gartner ctiWeb13 feb. 2024 · Here we identify a meiotic localizer of BRCA2, MEILB2/HSF2BP, that localizes to the site of meiotic DSBs in mice. Disruption of Meilb2 abolishes the localization of RAD51 and DMC1 recombinases in spermatocytes, leading to errors in DSB repair and male sterility. MEILB2 directly binds to BRCA2 and regulates its association to meiotic … gartner culture in a hybrid worldWebWe identify HSF2BP, a protein previously described as testis specific and not characterized functionally, as an interactor of BRCA2 in mouse embryonic stem cells, where the 2 proteins form a constitutive complex. HSF2BP is transcribed in all cultured human cancer ... [more] Cell Rep Dec. 25, 2024; 27 (13);3790-3798.e7 [ Pubmed: 31242413] Throughput gartner ctoWeb5 mrt. 2024 · HSF2BP-S167L females show reduced fertility with small litter sizes. To obtain mechanistic insights, we identified C19ORF57/MIDAP as a strong interactor and stabilizer of HSF2BP by forming a... gartner culture hacks