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Diversity outbred

WebAug 19, 2015 · Diversity Outbred (DO) mice are derived from incipient Collaborative Cross strains and represent a complementary resource with the same allelic diversity as the CC strains, maintained in a heterogeneous stock (Churchill et al. 2012; Chesler 2013). This population is an ideal resource for genetic mapping and selective breeding studies. WebJan 17, 2024 · While both outbred stocks offer significant individual heterozygosity, our data provide a molecular basis for their intended applications, where the J:DO are best suited for studies requiring maximum, population-level genetic diversity and power for mapping, while the J:ARC are best suited as a general-purpose outbred stock with robust ...

CXCL1: A new diagnostic biomarker for human tuberculosis discovered ...

WebSince our 2012 NAR report, we have added >70 new data sets, including data from Collaborative Cross lines and Diversity Outbred mice. During this time we have completely revamped our homepage, improved search and navigational aspects of the MPD application, developed several web-enabled data analysis and visualization tools, … WebDiversity Outbred mice were generated by breeding eight founder inbred strains together to produce a population with a random assortment of genetics (Figure 2). The eight founder strains were chosen specifically because of their unique characteristics. chris botti december https://allproindustrial.net

DODB - The Jackson Laboratory

WebJan 25, 2024 · It is unclear how standing genetic variation affects the prognosis of prostate cancer patients. To provide one controlled answer to this problem, we crossed a dominant, penetrant mouse model of prostate cancer to Diversity Outbred mice, a collection of animals that carries over 40 million SNPs. Inte … WebJul 28, 2024 · 2024 Joint Statistical Meetings (JSM) is the largest gathering of statisticians held in North America. Attended by more than 6,000 people, meeting activities include oral presentations, panel sessions, poster presentations, continuing education courses, an exhibit hall (with state-of-the-art statistical products and opportunities), career placement … WebAug 17, 2024 · Author summary More humans die of tuberculosis (TB) than any other infectious disease, yet diagnostic tools remain limited. Here, we used the Diversity Outbred mouse population to discover candidate protein biomarkers of human TB. By applying statistical methods and machine learning to multidimensional data, we identified CXCL1 … genshin impact fire tablet

Protein coding variation in the J:ARC and J:DO outbred laboratory …

Category:NTP Research Report on Baseline Characteristics of Diversity Outbred …

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Diversity outbred

NTP Research Report on Baseline Characteristics of Diversity …

WebThe use of genetically identical mice in toxicology studies can make it tricky to extrapolate findings to people. A new mouse model known as the Diversity Outbred better … WebDec 13, 2024 · We also show that genetic diversity in allegedly “outbred” colonies of nonmodel rodents (gerbils, hamsters, house mice, deer mice, and rats) varies considerably from nearly no segregating diversity to very high levels of polymorphism. We conclude that genetic divergence in isolated colonies may play an important role in the “replication ...

Diversity outbred

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WebThe recent introduction of the Collaborative Cross and Diversity Outbred mice, which share an extensive pool of genetic variation from eight founder inbred strains, presents new opportunities and challenges for community data resources. A wide variety of molecular and clinical phenotypes are being collected across genotypes, tissues, ages ...

Webtumor, Wei lab established a novel gene discovery platform of Diversity Outbred (DO) F1 mice that express HER2/Neu oncogene. Each mouse carries individually unique genetic composition that enables high-resolution linkage between genotype and phenotype. Using this platform, regulatory genes of tumor progression and vaccine response have been WebDiversity Outbred (J:DO) mice are a population of outbred animals with well-randomized genetic sequence polymorphisms and a genetic architecture similar to that of human …

WebDODB is a database that provides access to genotype and phenotype data from experiments with Diversity Outbred mice. Data can be searched by publication, investigator, and data type and can be downloaded in zipped CSV or R/QTL2 formats. Users can download full studies or a subset of samples, genotypes, clinical phenotypes and … WebTo investigate this, we utilized the Diversity Outbred (DO) and Collaborative Cross (CC) mouse models. DO mice are an outbred stock generated by crossbreeding eight …

WebDODB is a database that provides access to genotype and phenotype data from experiments with Diversity Outbred mice. Data can be searched by publication, …

WebA bioinformatics discovery platform of HER2/Neu-expressing Diversity Outbred (DO) F1 Mice was established to identify cancer-enabling genes. Quantitative Trait Loci (QTL) associated with onset ages and growth rates of spontaneous mammary tumors were sought. Twenty-six genes in 3 QTL contain sequence variations unique to the genetic … genshin impact firm arrowheadWebDec 2, 2024 · Here, we investigate the impact of genetic regulation on sex-specific gene expression using Diversity Outbred (DO) mice, an outbred population derived from eight inbred mouse strains [57, 58]. DO mice have high natural allelic variance [59, 60] and diverse phenotypes [61, 62], which facilitates fine genetic mapping of liver-specific traits. genshin impact fireworks smelting guideWebApr 12, 2024 · In the Smith Lab in MGM, she now leverages genetically diverse mice including well-known inbred lines, recombinant inbred panels (BXD, Collaborative Cross), and outbred panels (Diversity Outbred) to explore the many ways in which variation between unique individuals can predict TB disease outcomes. chris botti current band membersWebSep 14, 2024 · The JAX Diversity Outbred (J:DO) mice, for example, is a unique platform to test therapeutic interventions in a population that models the diversity seen in a human population. The JAX Diversity Mouse Portfolio. Here, we present the JAX Diversity Mouse Portfolio. These diversity models were generated with different breeding strategies, … genshin impact fir shelvesWebThe Diversity Outbred (DO) population is a heterogeneous stock derived from the same eight founder strains as the Collaborative Cross (CC) inbred strains. Genetically … chris botti gabriel\u0027s oboeWebApr 15, 2024 · In contrast, Diversity Outbred (DO) mice are a new population whose level of genetic diversity is on par with that of humans and nonhuman primates (NHPs) . The eight founding inbred strains that comprised the initial breeding pool for DO mice included traditional laboratory strains such as B6 and A/J, as well as three wild-caught mouse … chris botti houston 2023WebAug 15, 2012 · The Diversity Outbred (DO) population is a heterogeneous stock derived from the same eight founder strains as the Collaborative Cross (CC) inbred strains. Genetically heterogeneous DO mice display ... genshin impact first anniversary controversy