WebCytochalasans are a group of fungal-derived natural products characterized by a perhydro-isoindolone core fused with a macrocyclic ring, and they exhibit a high structural diversity and a broad spectrum of bioactivities. Cytochalasins are fungal metabolites that have the ability to bind to actin filaments and block polymerization and the elongation of actin. As a result of the inhibition of actin polymerization, cytochalasins can change cellular morphology, inhibit cellular processes such as cell division, and even cause cells … See more Cytochalasins are known to bind to the barbed, fast growing plus ends of microfilaments, which then blocks both the assembly and disassembly of individual actin monomers from the bound end. Once bound, … See more Actin microfilaments have been widely studied using cytochalasins. Due to their chemical nature, cytochalasins can help researchers … See more • Cytoskeletal drugs See more
Cytotoxic Bromine- and Iodine-Containing Cytochalasins …
WebNov 14, 2016 · Cytochalasins were the major secondary metabolites as detected and shown in Fig. 2, and this class of compounds is commonly found in Phomopsis genus. Antibacterial activity. The cytochalasins showed different degrees of antibacterial activities against the tested bacterial pathogens (Table 1). WebThe cytochalasins are natural occurring compounds that contain an isoindolone moiety fused to a macrocyclic lactone. These compounds have drawn the interest of the synthetic community based on a combination of their diverse … green and black pokemon
Cytochalasins - Product Information Sheet - Sigma-Aldrich
WebJul 12, 2024 · Alternariasin A (1), one new cytochalasin possessing the benzo[4,5]indeno[2,1-d]isoindole-1,3,13(2H,3aH)-trione skeleton, and five known … Web细胞骨架是指存在于真核细胞中的蛋白纤维网架体系. actin单体结合蛋白. 这些小分子蛋白与actin单体结合，阻止其添加到微丝末端，当 细胞需要单体时才释放，主要用于actin装配的调节，如proflin 等。. 微丝结合蛋白 微丝结合蛋白将微丝组织成以下三种主要形式 ... WebFeb 8, 2024 · elucidation of three [12]-cytochalasins, Z 7,Z 8, and Z 9, and two [13]-cytochalasins, E and K,4 from S. elegans. Our ongoing investiga-tions of the mass reculture of this species in the same media have led to the isolation of a further six new cytochalasins, Z 10-Z 15 (1-6), and one known [12]-cytochalasin (7). Compounds 1-6 … flower parade in holland