Cyp17a1蛋白
WebThe CYP17A1 gene provides instructions for making a member of the cytochrome P450 enzyme family. Like other cytochrome P450 enzymes, CYP17A1 is involved in the formation (synthesis) of steroid hormones. This group of hormones includes sex hormones such as testosterone and estrogen, which are needed for normal sexual development and … WebCYP17A1 ( シトクロム P450 17A1, steroid 17-alpha-monooxygenase 17α-hydroxylase/17,20 lyase/17,20 desmolase) はヒトにおいて CYP17A1 遺伝子がコードす …
Cyp17a1蛋白
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http://yuxiqbs.cqvip.com/Qikan/Search/Index?key=A%3d%e7%a8%8b%e6%b1%89%e5%85%b4 WebCYP17A1. Cytochrome P450 17A1 ( steroid 17α-monooxygenase, 17α-hydroxylase, 17-alpha-hydroxylase, 17,20-lyase, 17,20-desmolase) is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10. [5] It is ubiquitously expressed in many tissues and cell types, including the zona reticularis and zona ...
WebSep 26, 2024 · cyp17a1是雄激素产生过程中最重要的酶,而阿比特龙是针对此酶的抑制剂。 当CYP17A1酶被抑制以后,雄激素的产生将受阻。 恩杂鲁胺则是靶向作用于雄激素受体(AndrogenReceptor,AR)上的LBD结构域,使雄激素不能与AR结合,阻断AR信号通路。 Web进一步实验证实CPSF6是通过APA调节作用于下游靶点基因人宫颈癌癌基因2(HCCR2),使其具有缩短3'UTR的转录本高表达,翻译更多的蛋白,进而调节肝癌的增殖和转移过程。另外,实验中发现let-7a、let-7c、miR-26a三种miRNA结合在CPSF6基因3'UTR上直接抑制基因的 …
Web肾上腺皮质腺瘤CYP17A1及3BHSD2蛋白的免疫组化研究. 目的:应用免疫组织化学染色方法观察17α羟化酶 (CYP17A1),3β羟基类固醇脱氢酶2 (3BHSD2)在人正常肾上腺及其肿瘤组织中的分布特点,探讨CYP17A1,3BHSD2免疫组化检测对病理诊断肾上腺醛固酮分泌腺瘤 (APA),皮质醇分泌腺瘤 ... WebER stress增加PERK蛋白激酶活性,PERK磷酸化elF2,抑制蛋白翻译和合成,缓解ER压力。同时,elF2的磷酸化能够选择性地启动ATF4翻译,增加其结合配体的合成,影响氨基酸代谢,从而抑制蛋白的翻译和合成[6]。 正常 …
Web作为胆汁酸合成限速酶, cyp7a1的表达受饮食因素的调控. 日本研究者发现在7周龄的sd雄性大鼠中, 给予乳酸发酵的豆奶饲食5 wk后, rt-pcr显示肝组织中cyp7a1的mrna表达较对照 …
WebCYP19A1是细胞色素P450超家族(EC 1.14.14.1)的成员,它们是催化类固醇生成中许多反应的单加氧酶。. 特别地,芳香酶负责将雄激素芳构化为雌激素。. 芳香酶可以在许多组 … sacher historiaWeb重组蛋白: 多项发明专利,真核、原核表达系统稳定表达3000余种蛋白,生物活性良好; 产品定制: ELISA试剂盒、抗体、重组蛋白根据您需求可提供专业定制服务。 sacher knivesWeb把经过封闭的蛋白膜与稀释好的一抗4℃缓慢摇动过夜或室温缓慢摇动2小时,确保稀释的抗体至少能在摇动的瞬间覆盖蛋白膜。 ... CYP17A1 Rabbit Polyclonal Antibody. AF8067. 50μl. StAR Rabbit Polyclonal Antibody. AF6228. 50μl. ARF6 Rabbit Polyclonal Antibody. AF6234. 50μl. ASC/TMS1 Rabbit Polyclonal ... sacher houseWeb百度百科是一部内容开放、自由的网络百科全书,旨在创造一个涵盖所有领域知识,服务所有互联网用户的中文知识性百科全书。在这里你可以参与词条编辑,分享贡献你的知识。 sacher lawWeb目的 探讨细胞色素P450c17a酶 (CYP17A1)在人神经胶质瘤细胞系T98G,U87和U251中的表达情况.方法 采用Western blot和实时荧光定量PCR于蛋白质水平和mRNA水平检测细胞色素P450c17a酶 (CYP17A1)在三种人胶质瘤细胞系中的表达.结果 Western blot检测出CYP17A1蛋白在胶质瘤细胞系T98G,U251和 ... sacher law firmWebDefects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5) [MIM:202410]. AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to … is honesty always the best policyWebDec 1, 2024 · Cyp17a1 (Cytochrome P450 family 17 subfamily A member 1) is thought to play essential roles in fish steroidogenesis. Therefore, to further understand its roles in steroidogenesis, sex determination, and fertility in fish, we constructed a cyp17a1 gene mutant in Nile tilapia (Oreochromis niloticus). In XX fish, mutation of the cyp17a1 gene … is honesty out of style